Answer :
The substance that stimulates the pancreas to release bicarbonate-rich juice is secretin.
Secretin is a hormone that is produced in the small intestine in response to the presence of acidic chyme. It then travels through the bloodstream to the pancreas, where it stimulates the release of bicarbonate-rich juice to neutralize the acidity of the chyme. It controls the body's water balance and affects the environment of the duodenum by controlling secretions from the pancreas, liver, and stomach. The S cells of the duodenum, which are found in the digestive glands, generate this peptide hormone. The SCT gene in humans encodes the secretin peptide. By preventing gastric acid from being secreted by the parietal cells of the stomach and encouraging the synthesis of bicarbonate by the pancreatic ductal cells, secretin aids in maintaining the proper pH of the duodenum. By regulating the pH and enhancing the flow in the duct, it also increases the production of bicarbonate and water by cholangiocytes in the bile duct, protecting it from bile acids.
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